|
|
Recipients of L. H. Baker Center Postdoctoral Fellowship & Visiting Professor Support, 2008-2009
|
Dr. Zhen-zhen Zhang
Visiting Scholar, Department of Mathematics, Iowa State University, 2008-2009
Assistant Professor, Beijing University of Posts and Telecommunications
ISU Collaborator: Dr. Zhijun Wu , Department of Mathematics
Aim: Dr. Zhang will collaborate with Dr. Zhijun Wu to explore different methods to obtain relatively
accurate estimation of fluctuations of protein structures. The methods will include least-squares optimization within
the geometric buildup framework and the reduction of the Hessian matrix at different interaction levels. Dr. Zhang will
explore global optimization method for protein energy minimization. This work will advance protein structure refinement
whether the structure is from X-ray, NMR or comparative modeling.
|
Dr. Alexander A. Rashin
Research, BioChemComp Inc.
ISU Collaborator: Dr. Robert Jernigan, L H Baker Center
Aim: Most functionally important motions in protein are reducible to mutual movements of
rigid parts, however the kinases, exhibit a range of different functional motions, not reducible to rigid part
motions. Dr. Rashin will develop a method that allows making an objective distinction between rigid body motions,
plastic deformations and their various combinations. He will use this method to explore whether the motion patterns
of kinases correlate with the subdivision of the human kinome into groups, families and subfamilies. This will deepen
our understanding of structure and function of kinase, which include up to 1.7% of all human genes.
|
Dr. Catherine M Logue
Visiting Proferssor, Department of Veterinary Microbiology and Preventive Medicine,
Iowa State University, 2008-2009
Associate Professor
Department of Veterinary and Microbiological Sciences
North Dakota State University
ISU Collaborator: Dr. Lisa Nolan ,
College of Veterinary Medicine
Department of Veerinary Microbiology and Preventive Medicine
Aim: This will partially support Dr. Catherine M Logue to pursue a sabbatical research program
in microbial genomics and bioinformatics and train in cutting-edge research at Iowa State University, The sabbatical
will entail a study of the application of functional genomics and bioinformatics in Escherichia coli and
determine how this can be translated into a similar research approach for Salmonella and Campylobacter .
|
|
