Infectious Diseases

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CBAA Faculty in this research area using multiple, complementary approaches to understand host-pathogen interactions and discern the genetic basis of microbial virulence. Several CBAA faculty are exploring the use of microarray technology for comparative analyses of gene expression in virulent and avirulent organisms, or in resistant and susceptible hosts. Other CBAA faculty are utilizing the wealth of information that can be extrapolated by tracing patterns of evolutionary change to identify important factors in viral pathogenesis and to predict genetic determinants of pathogen virulence. These data are being used to develop mathematical models of disease that will aid in design and evaluation of therapeutic strategies of disease intervention.

Additional research efforts of CBAA faculty are focused on discerning the immune response to pathogens, including viral, bacterial and parasitic infections. In each case, these CBAA faculty are using model systems to analyze immunoregulatory factors that influence the development of an immune response in vivo. A unifying theme in each model system is discerning the immunoregulatory networks that mediate the host response to infection. 

For additional information:
Email: mget@iastate.edu
Phone: (515) 294-7937

URL: http://www.bioinformatics.iastate.edu/MGET/
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Last Modified July 29, 2005 kmw