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Bioinformatics and Computational Biology Summer Institute |
Research Projects for Fellows, June 20 - August 6, 2005
P9: GeneChip transcript patterns over time in barley-powdery mildew interactions and programmed cell death
| Title: | GeneChip transcript patterns over time in barley-powdery mildew interactions and programmed cell death |
| Mentors: | Dr. Roger Wise and Dr. Rico Caldo |
| Description: | Hypersensitive cell death plays a pivitol role in the restriction of pathogen development. However, many genes controlling programmed cell death are independent of those involved in resistance/signaling specificity in bacteria-, virus-, and fungal-plant interactions. Interns will analyze real-world 22K Barley1 GeneChip data from a powdery-mildew resistant genotype as compared to a derived fast neutron mutant controlling programmed cell death over time. Patterns of gene expression will be determined as well as predictions of gene function in cell-death pathways. |
| Web Resources: | http://barleybase.org http://plexdb.org |
| References: | 1: Caldo, RA, D Nettleton and RP Wise. 2004. Interaction-dependent gene expression in Mla -specified response to barley powdery mildew. Plant Cell. 16: 2514-2528 2: Close, TJ, S Wanamaker, R Caldo, SM Turner, DA Ashlock, JA Dickerson, RA Wing, GJ Muehlbauer, A Kleinhofs and RP Wise. 2004. A new resource for cereal genomics: 22K barley GeneChip comes of age. Plant Physiology 134: 960-968 3: Shen, L, J Gong, RA Caldo, D Nettleton, D Cook, RP Wise, and JA Dickerson. 2005. BarleyBase-an expression profiling database for plant genomics. Nucleic Acids Research 33: D614-D618 |