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Computational and Systems Biology Summer Institute |
Research Projects for Fellows, 2009
P10: Analysis and prediction of macromolecular (protein-protein, protein-RNA, protein-DNA) interfaces
| Short Title: | Analysis and prediction of macromolecular (protein-protein, protein-RNA, protein-DNA) interfaces |
| Mentors: | PI: Vasant Honavar, Collaborators: Dobbs, Jernigan. Graduate Students: Cornelia Caragea, Raphael Jordan |
| Description: |
We have developed machine learning approaches to analysis and prediction of protein-protein, protein-DNA, protein-RNA interfaces from amino acid sequence (and whenever available), protein structure. We have also constructed comprehensive databases of protein-protein and protein-RNA interfaces. We are especially interested in characterization of structural and physicochemical characteristics of interfaces. Work in progress is aimed at developing reliable predictors of protein-protein and protein-nucleic acid interfaces. |
| Web Resources: | http://ppidb.cs.iastate.edu/ http://bindr.gdcb.iastate.edu/RNABindR/ http://turing.cs.iastate.edu:8080/PredDNA/ |
| References: | |
| Suitable background skills: |