Research Projects for Fellows, 2009
P06: Developing an Annotated Structural Database of Binding Sites
| Short Title: |
Developing an Annotated Structural Database of Binding Sites |
| Mentors: |
Dr. Robert Jernigan, , Dr. Andrzej Kloczkowski, Ataur Katebi |
| Description: |
One of the most important functions of proteins is to bind in highly specific ways to various ligands - other proteins, DNA, RNA and various small molecules. Developing this database together with an interface to perform structural matches will facilitate comparisons among binding sites for similar ligands.
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| Web Resources: |
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| References: |
For guidelines for how to define a binding site - see Sen, T.Z., Kloczkowski, A., Jernigan, R.L., Yan, C., Honavar, V., Ho, K.M., Wang, C.Z., Ihm, Y., Cao, H., Gu, X. and Dobbs, D. Predicting binding sites of hydrolase-inhibitor complexes by combining several methods, BMC Bioinformatics 2004; 5: 205. |
| Suitable background skills: |
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